Selected Recent Publications

Han, Z.; Lu, J.; Liu, Y.; Davis, B.; Lee, M. S.; Olson, M. A.; Ruthel, G.; Freedman, B. D.; Schnell, M. J.; Wrobel, J. E.; Reitz, A. B.; and Harty, R. N. “Small Molecule Probes Targeting the Viral PPxY-Host Nedd4 Interface Block Egress of a Broad Range of RNA Viruses.” Journal of Virology, 2014, 88, 7294-7306.

McDonnell, M. E.; Bian, H.;Wrobel, J.; Smith, G. R.; Liang, S.; Ma, H.; Reitz, A. B. Anilino-monoindolylmaleimides as potent and selective JAK3 inhibitors. Bioorg Med Chem Lett. 2014, 24, 1116-1121.

Caglic, D.; Krutein, M. C.; Bompiani, K. M.; Barlow, D. J.; Benomi, G.; Pelletier, J. C.; Reitz, A. B.; Lairson, L. L.; Houseknecht, K. L.; Smith, G. R.; Dickerson, T. J. Identification of clinically viable quinolinol inhibitors of botulinum neurotoxin A light chain. J. Med. Chem. 2014, 57, 669-676.

Smith, G. R.; Brenneman, D. E.; Zhang, Y.; Du, Y.; Reitz, A. B. Small-Molecule Anticonvulsant Agents with Potent In Vitro Neuroprotection and Favorable Drug-Like Properties. J. Mol. Neurosci. 2014, 52, 446-458.

Gregg, R. A.; Tallarida, C. S.; Reitz, A. B.; McCurdy, C.; Rawls, S. M. Mephedron (4-methylmethcathinone), a principal constituent of psychoactive bath salts, produces behavioral sensitization in rats. Drug Alcohol Depend. 2013, 133, 746-750.

Gregg, R. A.; Tallarida, C. S.; Reitz, A. B.; Rawls, S. M. Mephedrone interactions with cocaine: prior exposure to the ‘bath salt’ constituent enhances cocaine-induced locomotor activation in rats. Behavioural Pharmacology 2013, 24, 684-688.

Watterson, D. M.; Grum-Tokars, V. L.; Roy, S. M.; Schavocky, J. P.; Bradaric, B. D.; Bachstetter, A. D.; Xing, B.; Dimayuga, E.; Saeed, F.; Zhang, H.; Staniszewski, A.; Pelletier, J. C.; Minasov, G.; Anderson, W. F.; Arancio, O.; Van Eldick, L. J. Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction. PLoS ONE 2013, 8(6), e66226.

Ramoz, L.; Lodi, S.; Bhatt, P.; Reitz, A. B.; Tallarida, C.; Tallarida, R. J.; Raffa, R. B.; Rawls, S. M. Mephedrone ('Bath Salt') Pharmacology: Insights from Invertebrates, Neuroscience, 2012, 208, 79-84.

Lisek, R.; Yuvasheva, E.; Chiu, Y. T.; Reitz, A. B.; Liu-Chen, L. Y.; Rawls, S. M. Mephedrone (‘Bath Salt’) Elicits Conditioned Place Preference and Dopamine-Sensitive Locomotor-Sensitive Activation. Drug and Alcohol Dependence, 2012, 126, 257-262.

Cassel, J. A.; Ilyin, S.; McDonnell, M. E.; Reitz, A. B. Novel Inhibitors of Heat Shock Protein Hsp70-Mediated Luciferase Refolding that Bind to DnaJ, Bioorg. Med. Chem. Lett. 2012, 20, 3609-3614.

Cassel, J. A.; McDonnell, M. E.; Velvadapu, V.; Andrianov, V.; Reitz, A. B. The effects of small molecule inhibitors of nucleic acid binding to TDP-43 on TDP-43 metabolism and function. Biochimie, 2012, 94, 1974-1981.

Smith, G. R.; Caglič, D.; Čapek, P.; Zhang, Y.; Godbole, S.; Reitz, A. B.; Dickerson, T. J. Reexamining hydroxamate inhibitors of Botulinum neurotoxin serotype A: Extending towards the b-exosite. Bioorg. Med. Chem. Lett. 2012, 22, 3754-3757.

McDonnell, M. E.; Vera, M. D.; Blass, B. E.; Pelletier, J. C.; King, R. C.; Fernandez-Metzler, C.; Smith, G. R.; Wrobel, J.; Chen, S.; Reitz, A. B. Riluzole prodrugs for melanoma and ALS: design, synthesis, and in vitro metabolic profiling. 2012, Bioorg. Med. Chem., 20, 5642-5648.

Velvadapu, V., McDonnell, M. E., Jaffe, E. K., Reitz, A. B.  Facile Synthesis of Mutagen X (MX): 3-Chloro-4-(dichloromethyl)-5-hydroxy-5H-furan-2-one. Tetrahedron Letters, 2012, 53, 3144-3146.

Brenneman, D. E.; Smith, G. R.; Zhang, Y.; Du, Y.; Kondaveeti, S. K.; Zdilla, M. J.; Reitz, A. B.  Small-Molecule Anticonvulsant Agents with Potent in vitro Neuroprotection. J. Molecular Neuroscience, 2012, 47, 368-379.

Venkatesh, M., Wang, H., Cayer, J., Leroux, M., Salvail, D., Das, B., Wrobel, J., Mani, S. In Vivo and In Vitro Characterization of a Frist-in-Class Novel Azole Analog That Targets Pregnane X Receptor Activation. Molecular Pharmacology, 2011, 80, 124-135.

Čapek, P., Zhang, Y., Barlow, D.J., Houseknecht, K.L., Smith, G., Dickerson, T.J. Enhancing the Pharmacokinetic Properties of Botulinum Neurotoxin Serotype A Protease Inhibitors through Rational Design. ACS Chemical Neuroscience, 2011, 2, 288-293.

Reitz, A. B.; Ramirez, U. D.; Stith, L.; Du, Y.; Smith, G. R.; Jaffe, E. K. Pseudomonas aeruginosa Porphobilinogen Synthase Assembly State Regulators: Hit Discovery and Initial SAR Studies. ARKIVOC, 2010, 175-188.

Reitz, A. B.; Smith, G. R.; Tounge, B. A.; Reynolds, C. H. Hit Triage Using Efficiency Indices after Screening of Compound Libraries in Drug Discovery. Curr. Top. Med. Chem., 2009, 9, 1718-1724.